Scott

 

Craig Scott                   Cell and Molecular Biologist Assistant Professor Training BS Biology - SUNY Oneonta, NY PHD Cell, Molecular, and Development Biology, Pittsburgh, PA Contact: (W) 814-393-2560 Email:  cscott@clarion.edu Office: Rm 257 STC

Professional Associations

Research Interests

Liver disease, diabetes, cancer, cystic fibrosis, and a variety of neurodegenerative disorders are just a few of the diseases linked to aberrant protein production during endoplasmic reticulum (ER) stress and ER quality control.  Many of these disorders can be traced back to the manufacturing of a single aberrant protein and the inability of the cell to remove it efficiently.  However, studies of diseases, such as Anti-Trypsin Disease (ATD), have shown that efficient degradation or secretion of the aberrant protein can yield a normal phenotype within the patient.  ATD is a genetic disorder that leads to liver and lung disease.  Thus, there has been a directed focus on elucidating the mechanisms of protein quality control and production in these diseases in recent years.  These studies have lead to major insights into the pathophysiology of disease processes, as well as to potential treatments.  As a continuation of these initial works, my lab works focuses on the genetic mechanisms that regulate protein production during these times of cellular stress.  Our ultimate goal is to further elucidate the mechanism of cell stress and responses in eukaryotic cells as well as to provide insights into genetic disorders relating to cell stress.

Recent Publications

Tonsor S.J., Scott C.M., Boumaza I., Liss T.R., Brodsky J.L., and E.  Vierling.  (2008) Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions.  Molecular Ecology 17:1614-26

Brodsky, J.L. and C.M. Scott (2007) Tipping the Delicate Balance:  Defining How Proteasome Maturation Affects the Degradation of a Substrate for Autophagy and Endoplasmic Reticulum Associated Degradation (ERAD.) Autophagy 3:623-625

Scott, C.M., K.B. Kruse, B.Z. Schmidt, D.H. Perlmutter, A.A. McCracken, and J.L. Brodsky (2007) ADD66, a Gene Involved in the Endoplasmic Reticulum Associated Degradation (ERAD) of Alpha-1-Antitrypsin-Z in Yeast, Facilitates Proteasome Activity and Assembly. Mol. Biol. Cell 18:3776-3787

Commonwealth of Pennsylvania University Biologists (CPUB)

Northeast Association of Advisors of the Health Professions (NEAAHP)

National Association of Advisors of the Health Professions (NAAHP)

American Society Cell and Molecular Biology

Courses Taught

BIOL 111 Basic Biology

BIOL 155 Principles of Biology

BIOL 203 Cell Biology

BIOL 464 Developmental Biology

BIOL 485 Biotechnology

BIOL 495 Undergraduate Seminar